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Eight human genes have been recognised as modulating blood pressure by a team from London, UK. Prof. Caulfiled tells about this research that will provide targets for new drugs to treat hypertension.
Milan, Italy – Eight human genes have been discovered which-collectively-may contribute substantially to the burden of hypertension in communities, that’s according to research presented at the European Meeting on Hypertension by Mark Caulfield, MBBS MD FRCP, Professor of Clinical Pharmacology at Barts and The London School of Medicine, and Director of the William Harvey Research Institute.
After his presentation in Milan, he said in an interview that although the newly identified genes individually each have small effects, the overall effect may be large, because several such common genes for high blood pressure may be expressed in the same patient causing an additive effect.
“The effects that we saw were one, or half a millimetre (of mercury) of blood pressure, and you may say: that’s a bit disappointing. On the other hand, small differences in blood pressure across a whole population greatly affect risk of stroke and heart attack, so the aggregate of our findings-elevating blood pressure by two millimetres of mercury- could make a six per cent difference to stroke and about a five per cent difference to coronary disease risk,” he said.
The findings have recently been published (Nature Genetics 2009 41: 666-676) in a study with 71 225 people in whom relevant genes were located in 34 433-in other words: they are clearly common genes possessed by half of the population surveyed.
His main interest in doing this research, Professor Caulfield explained, was in developing new medicines. Even though such genes individually may have small effects, they give starting points for drug design which, historically, has yielded large therapeutic effects even from small differences in molecular function discovered by scientists.
And the genes the London scientists have spotted possess other important functions which promise to help elucidate disease mechanisms and the design molecular therapies. Among these are pro-thrombotic activities and also angiotensin, naturietic peptide, and steroid synthesis. Professor Caulfield believes these all have therapeutic potential: “The variations that we found identified a number of regions which contained some genes that could be good candidates for affecting blood pressure-also, the naturietic peptides represent potential therapeutic targets,” he said.
“These are the first robust genes and (together with findings from another publication) we now have 13 genes for hypertension which are identified for systolic and diastolic blood pressure.”
ESH 2009 – Best Selected Posters
During the ESH 2009 Annual Meeting a specially appointed Committee selected daily (June 13,14 & 15) the 10 best posters presented.
Each selected poster will receive an award of € 500.
The Authors of the selected posters will be notified shortly.
JUNE 13 – 10 Best Selected Posters
Decreasing Of Nadroparine Doses Have Influence On Blood Pressure In Haemodyalised Patients
M. Sain, D. Ljutic, V. Kovacic, J. Radic, I. Jelicic, M. Radic
Initiation Of Antihypertensive Treatment Within 24 Hours Of Onset Of Ischemic Stroke
L. Brescacin, C. Alonzo, M.C. Zurru, S. Brienza, M.B. Piaggio,M. Romano, L.A. Camera, E. Cristiano, G. Waisman
Initiation Of Antihypertensive Treatment Within 24 Hours Of Onset Of Ischemic Stroke
L. Brescacin, C. Alonzo, M.C. Zurru, S. Brienza, M.B. Piaggio,M. Romano, L.A. Camera, E. Cristiano, G. Waisman
Poor Compliance Is Accompanied With Cardiovascular Complications And New Onset Diabetes In Hypertensive Patients On Monotherapy
R.E Schmieder , A. Kulschewski , K. Kostev , O. Pirk , J. Mathes
Prevalence Of Hypertension And Obesity In Working Population Of Bank Employers
O.P. Rotar, A.O. Konrady, L.S. Korostovtseva, K.T. Kitalaeva, V.V. Ivanenko, M.V. Avdeeva, V.N. Solntcev, S.B. Anokhin, V.A. Bart
Influencing Factors For Therapeutic Choice In Hypertensive Patients Uncontrolled With A Two-Drug Therapy: Observational Study Recours
B. Fiquet , S. Quere , A. Francillon , M. Galinier
Inflammation And Essential Hypertension: Correlations Of C-Reactive Protein With Dimensions Of Health Related Quality Of Life
V. Katsi, D. Tsartsalis, I. Skiadas, K. Kontoangelos, K. Koundi, P. Sakkas, C. Stefanadis, I. Kallikazaros
Effects Of Digoxin On Muscle Reflexes In Normal Humans
C. Janssen, O. Lheureux, S. Beloka, G. Deboeck, D. Adamopoulos, R. Naeije, P. Van De Borne
Aerobic Interval Training Decreases Blood Pressure More Than Moderate Intensity Training In Patients With Essential Hypertension
H.E. Molmen Hansen, T. Stolen, A.E. Tjonna, I.L. Aamot, I. Schjerve Ekeberg, G. Tyldum, U. Wisloff, C. Bjork Ingul, A. Stoylen
JUNE 14 – 10 Best Selected Posters
Electrical Carotid Sinus Stimulation Reduces Sympathetic Activity And Blood Pressure In Patients With Refractory Hypertension
K. Heusser, J. Tank, A. Diedrich, S. Engeli, J. Menne, S. Eckert, F.C. Sweep, H. Haller , F.C. Luft , J. Jordan
Exercise Blood Pressure And Risk Of Future Hypertension
L. Mortensen, L. Holmqvist, C. Ljungman, C. Kanckos, K. Manhem
The Uric Acid As A Risk Factor For Atherosclerosis In Menopausal Women
C. Homentcovschi, A. Gurghean, S. Avram, I. Bruckner
Can We Manage Patients With Metabolic Syndrome According To The Recommendations Esh-Esc 2007? An Algerian Urban Multi-Center Study
N.N. Ali-Tatar , R. Guermaz , D. Hakem , H. Moualek ,B. Mohammedi , M. Brouri , A. Berrah , M.T. Chentir
Evaluation Of Endothelial Function And Vascular Thickness In Refractory Arterial Hypertensive Patients
J.C. Yugar-Toledo , L.A. Souza , D.R.S. Souza , S. Ubaid-Girioli , S.E.S.F.C. Melo , L.C. Martins ,L.M.B. Martins , A. Gazzoto , S. Sultano, M.F. Consolin Colombo , O. Rizzi Coelho,
J.F. Vilela Martin , H. Moreno Jr
Risk Factors Associated To Target Organ Damage In Hypertensive Patients: The Role Of Heart Rate
V. Pallares-Carratala, L. Facila-Rubio, V. Bertomeu-Gonzalez, M. Perez-Alonso, V. Montagud
Assessment Of Left Ventricular Hypertrophy: Ekg, Echocardiography, Or Nt-Probnp?
N. Gaudebout, C. Mouly-Bertin, L. Legedz, G. Bricca, H. Milon, P. Lantelme
Levosimendan: Improves Cardiac Performance Through Decreases Of Sympathetic Activity
F. Despas, C. Trouillet, N. Franchitto, M. Galinier, J.M. Senard, A. Pathak
Noninvasive Ventilation In Hypoxic Vs Hypercapnic Presentation Of Acute Cardiogenic Pulmonary Edema
T.S.Z. Soliman, A.A.M. El Malki
The Epidemiological Characteristics Of Lipids-Body Weight And Hypertension In Chinese Rural Elderly And Very Elderly Population
X.L. Wang, X.X. Huang, S.J. Liang, G.L. Liu, J.L. Xu, X.Y, Wang, H.Y. Zhang, L.S. Liu
JUNE 15 – 10 Best Selected Posters
Sleep Blood Pressure And Variability Determined By Sleep Quality Is Associated With Silent Cerebral Infarction
S. Hoshide, K. Shimada, K. Kario
Evaluation Of The Relationship Between Waist Circumference And Target Organ Damage With Or Without Metabolic Syndrome
R. Rugale, G. Du Cailar, J. Ribstein, A. Mimran
Left Atrial Size, Flow-Mediated Dilation Of Brachial Artery And Target Organ Damage In Hypertensive Patients
J. Xu, P. Gao, Y. Zhang, S. Wu
Family History Of Hypertension Is Related To Diastolic Function In Hypertensive And Nonhypertensive Patients. Echocardiographic Study
I. Burazor, S. Stefanovic, V. Stefanovic, M. Burazor, M. Milanovic, A. Velickovic, M. Krstic
Changes In Brain Natriuretic Peptide Predict 1-Year Outcome Independently Of Renal Function In The Elderly With Acute Heart Failure
S. Verde, S Pirelli, G Di Tano, R. De Maria
Is The Spot Urinary Sodium/Creatinine Ratio A Reliable Estimate Of Sodium Consumption?
A. Pechere-Bertschi, S. Beer-Borst, A. Morabia, M. Burnier
Endothelial Dysfunction Is Associated With Arterial Stiffness In Hypertensive Patients With Type 2 Diabetes Mellitus
R.M. Bruno, L. Ghiadoni, A.G. Daniele, G. Penno, F. Stea, L. Landini, S. Del Prato, S. Taddei, A. Salvetti
Coronary Functional Alterations In A New Porcine Model Of Diabetes Mellitus Type 2
M. Van Den Heuvel, O. Sorop, R. De Vries, H. Van Beusekom, S.J. Koopmans, D.J. Duncker, A.H. Danser, W.J. Van Der Giessen
Effects Of Melatonin And Pycnogenol, Substances With Antioxidant Properties, On The Structure And Function Of Small Mesenteric Arteries Of Spontaneously Hypertensive Rats
E. Porteri, S. Paiardi, R. Rezzani, L.F. Rodella, C. De Ciuceis, G.E.M. Boari, S. Tengattini, F. Bonomini, D. Rizzoni, N. Rizzardi, C. Platto, A. Pilu, E. Agabiti Rosei
Resistant Hypertension In Elderly Patients: Nondipper Pattern And Chronotherapy
J.L. Lopez, A. Hermida, M. Pazo, M.L. Romero, G. Calvo, A. Pose, M. Pena, C. Calvo